Synthesis and anti-HIV-1 activities of novel podophyllotoxin derivatives

SW Chen, YH Wang, Y Jin, X Tian, YT Zheng…

Index: Chen, Shi-Wu; Wang, Yun-Hua; Jin, Yan; Tian, Xuan; Zheng, Yong-Tang; Luo, Du-Qiang; Tu, Yong-Qiang Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 7 p. 2091 - 2095

Full Text: HTML

Citation Number: 58

Abstract

In order to explore the range of biological activities of the podophyllotoxin compound class, a novel series of derivatives of podophyllotoxin, which were conjugates containing stavudine and different structural podophyllotoxin analogues, were designed, synthesized, and evaluated for their anti-HIV-1 activities in vitro. Among these compounds, 19d and 19c showed the highest anti-HIV-1 activities with EC50 values of 0.17 and 0.29 μM and TI ...