Tyrosine Kinase Inhibitors. 4. Structure-Activity Relationships among N-and 3-Substituted 2, 2'-Dithiobis (1H-indoles) for in vitro Inhibition of Receptor and Nonreceptor …
BD Palmer, GW Rewcastle, AM Thompson…
Index: Rewcastle, Gordon W.; Denny, William A. Heterocycles, 1994 , vol. 37, # 2 p. 701 - 708
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Citation Number: 66
Abstract
A series of 3-substituted 2, 2'-dithiobis (lH-indoles) were synthesized and evaluated for their ability to inhibit the tyrosine kinase activity of both the epidermal growth factor receptor (EGFR) and the nonreceptor pp60v-src tyrosine kinase, to extend the available structure-
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