Vinyl sulfones as mechanism-based cysteine protease inhibitors

…, D Rasnick, JL Klaus, D Bromme

Index: Palmer, James T.; Rasnick, David; Klaus, Jeffrey L.; Broemme, Dieter Journal of Medicinal Chemistry, 1995 , vol. 38, # 17 p. 3193 - 3196

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Citation Number: 450

Abstract

Proteases regulate a broad spectrum of physiological functions by the specific processing of proteins and peptides. Elevated levels of active proteases can result in an array of physiological processes ultimately leading to disease states. Therefore, compounds designed to restore the natural equilibrium of proteases present excellent opportunities for drug candidates. Cysteine proteases, for example cathepsins B, L, and S, have been ...