Tetrahedron Letters

Total synthesis of antifungal gamahonolide A

G Sabitha, KP Reddy, SP Reddy, JS Yadav

Index: Sabitha, Gowravaram; Reddy, K. Purushotham; Reddy, S. Purushotham; Yadav Tetrahedron Letters, 2014 , vol. 55, # 21 p. 3227 - 3228

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Abstract

6-Substituted α,β-unsaturated δ-lactone moiety containing natural products attracted the attention of synthetic chemists due to their interesting structure and potential biological activities. The activities include antiviral, antifungal, antibacterial, growth inhibitory, antitumor, and antileukemic. 1 and 2 Gamahonolide A 3 (1) is a δ-lactone, isolated from stromata of phytopathogenic fungus, Epichloe typhina on Phleum pratense. E. typhina causes choke disease to the pasture grass, ...