Synthesis and Biological Activity of 5-Alkyl-1, 7, 8-trisubstituted-6-fluoroquinoline-3-carboxylic Acids

…, JM Domagala, CL Heifetz, J Johnson

Index: Hagen, Susan E.; Domagala, Johan M.; Heifetz, Carl L.; Johnson, Judith Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 1155 - 1161

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Citation Number: 49

Abstract

The quinolones prepared for this study were tested against 10 representative Gram-negative and Gram-positive organisms by using standard microtitration technique~.~~ The minimum inhibitory concentrations (MICs, in pg/mL) are presented in Table 111. In order to facilitate comparisons in activity between compounds, the geometric means of the MICs were calculated for both Gram-positive and Gram-negative strains and are included in Tables IV ...