Tetrahedron

Solvent-free Knoevenagel condensations and Michael additions in the solid state and in the melt with quantitative yield

G Kaupp, MR Naimi-Jamal, J Schmeyers

Index: Kaupp, Gerd; Naimi-Jamal, M. Reza; Schmeyers, Jens Tetrahedron, 2003 , vol. 59, # 21 p. 3753 - 3760

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Citation Number: 255

Abstract

Numerous Knoevenagel condensations of solid or liquid aromatic aldehydes are performed with four barbituric acids, Meldrum's acid, dimedone, cyanoacetamide, malodinitrile and methyl cyanoacetate in stoichiometric mixtures of the solids or of stoichiometric melts. The product yields are quantitative in 23 reported cases and the products do not require purifying workup. Therefore, these reactions are truly solvent-free, atom economic and sustainable ...