Syntheses of Prekinamycin and a Tetracyclic Quinone from Common Synthetic Intermediates

…, T Kumamoto, A Akagi, N Sato, T Ishikawa

Index: Kimura, Shingo; Kobayashi, Satoshi; Kumamoto, Takuya; Akagi, Aki; Sato, Naomi; Ishikawa, Tsutomu Helvetica Chimica Acta, 2011 , vol. 94, # 4 p. 578 - 591

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Citation Number: 13

Abstract

Abstract Towards total synthesis of a series of kinamycin and related antibiotics via common synthetic intermediates, total synthesis of prekinamycin was achieved via Suzuki coupling of naphthaleneboronic acid and bromobenzene derivative, intramolecular Friedel [BOND] Crafts reaction of 2-(naphthalen-2-yl) benzoic acid, and diazotization in ten steps from 3, 5- dimethylphenol. Synthetic studies towards kinamycin antibiotics was also examined, and ...