Hybrid molecules: Growth inhibition of leishmania donovani promastigotes by thiosemicarbazones of 3-carboxy-. beta.-carbolines
…, C Ouannes, M Robert-Gero, P Potier
Index: Dodd; Ouannes; Robert-Gero; Potier Journal of Medicinal Chemistry, 1989 , vol. 32, # 6 p. 1272 - 1276
Full Text: HTML
Citation Number: 44
Abstract
The thiosemicarbazones of@-carboline-3-carboxaldehyde (compound 2) and 3-acetyl-@- carboline (compound 3) were found to effectively inhibit the in vitro growth of the promastigote form of Leishmania donovani, 50% inhibition being obtained at concentrations of 5.0 and 2.5 pM, respectively, while irreversible growth inhibition was achieved at 40 (compound 2) and 17.5 pM (compound 3). The thiosemicarbazone of pyridine-2- ...
Related Articles:
Three-component synthesis of polysubstituted 6-azaindolines and its tricyclic derivatives
[Dodd, Robert H.; Doisy, Xavier; Potier, Pierre; Potier, Marie-Claude; Rossier, Jean Heterocycles, 1989 , vol. 28, # 2 p. 1101 - 1113]
Three-component synthesis of polysubstituted 6-azaindolines and its tricyclic derivatives
[Dodd, Robert H.; Doisy, Xavier; Potier, Pierre; Potier, Marie-Claude; Rossier, Jean Heterocycles, 1989 , vol. 28, # 2 p. 1101 - 1113]
Three-component synthesis of polysubstituted 6-azaindolines and its tricyclic derivatives
[Dodd, Robert H.; Doisy, Xavier; Potier, Pierre; Potier, Marie-Claude; Rossier, Jean Heterocycles, 1989 , vol. 28, # 2 p. 1101 - 1113]