Syntheses and antibacterial activity of a series of 3-(pyridine-3-yl)-2-oxazolidinone
Y Cui, Y Dang, Y Yang, S Zhang, R Ji
Index: Cui, Yingjie; Dang, Yaxian; Yang, Yushe; Zhang, Shuhua; Ji, Ruyun European Journal of Medicinal Chemistry, 2005 , vol. 40, # 2 p. 209 - 214
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Citation Number: 43
Abstract
The syntheses of substituted piperazinyl pyridyl oxazolidinones 8–16 are described. Their in vitro activities against Gram-positive organisms such as Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus and enterococcus were evaluated by minimum inhibitory concentration (MIC) determination. Compound 8 and 10 were found to be superior to linezolid.
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