Synthesis and in vitro bronchospasmolytic activity of 8-aryl, heteroaryl or arylalkyl theophyllines

G Baziard-Mouysset, A Rached, S Younes…

Index: Baziard-Mouysset, G.; Rached, A.; Younes, S.; Tournaire, C.; Stigliani, J. L.; et al. European Journal of Medicinal Chemistry, 1995 , vol. 30, # 3 p. 253 - 260

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Citation Number: 9

Abstract

Twenty-four 8-aryl-or 8-heteroaryl-substituted theophyllines have been synthesized. The substituents are aromatic rings and heterocycles likely to induce an antiallergic effect or a spasmolytic activity. In vitro evaluation of the bronchospasm caused by acetylcholine or histamine shows an interesting activity for half of the compounds. Among them, the furanic 111s and 2-chlorophenyl IIIi derivatives are, for instance, four times more active than ...