Convenient indole synthesis from ethynylanilines with a polymer-supported fluoride
A Yasuhara, N Suzuki, T Yoshino, Y Takeda…
Index: Yasuhara, Akito; Suzuki, Naoyuki; Yoshino, Takashi; Takeda, Yousuke; Sakamoto, Takao Tetrahedron Letters, 2002 , vol. 43, # 37 p. 6579 - 6582
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Citation Number: 22
Abstract
The cyclization reaction of ethynylanilines having phenyl, alkyl, methoxy, cyano, chloro, and ethoxycarbonyl groups with (polystyrylmethyl) trimethylammonium fluoride in dry MeCN under an argon atmosphere at 100° C proceeded in good yields to give the corresponding indoles without affecting these functional groups. Moreover, the polymer-supported fluoride could be reused for the cyclization reaction when the deprotection reaction of the N- ...
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