Total synthesis and selective activity of a new class of conformationally restrained epothilones

…, RA Hudson, L Perera, LM Tillekeratne

Index: Alhamadsheh, Mamoun M.; Gupta, Shuchi; Hudson, Richard A.; Perera, Lalith; Tillekeratne, L. M. Viranga Chemistry - A European Journal, 2008 , vol. 14, # 2 p. 570 - 581

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Citation Number: 15

Abstract

Abstract Stereoselective total syntheses of two novel conformationally restrained epothilone analogues are described. Evans asymmetric alkylation, Brown allylation, and a diastereoselective aldol reaction served as the key steps in the stereoselective synthesis of one of the two key fragments of the convergent synthetic approach. Enzyme resolution was employed to obtain the second fragment as a single enantiomer. The molecules were ...