Tetrahedron

Stereoconvergent synthesis of a potent mosquito larvicide:(2E, 4E, 8E, 10Z)-N-(2-methyl propyl)-2, 4, 8, 10-dodecatetraeneamide

GVM Sharma, T Shekharam, V Upender

Index: Sharma, G. V. M.; Shekharam, T.; Upender, V. Tetrahedron, 1990 , vol. 46, # 16 p. 5665 - 5672

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Citation Number: 14

Abstract

First total synthesis of (2E, 4E, 8E, 10Z)-N-(2-methyl propyl)-2, 4, 8, 10-dodecatetraene amide (1), by the condensation of (4E, 6Z)-octadienyl phenyl sulfone (2) and ethyl-4- oxobutanoate (3) followed by double elimination reaction, which involves easily accessible reagents and simple transformations is described.