Chemoenzymatic synthesis of structured triacylglycerols by highly regioselective acylation

A Halldorsson, CD Magnusson, GG Haraldsson

Index: Halldorsson, Arnar; Magnusson, Carlos D.; Haraldsson, Gudmundur G. Tetrahedron, 2003 , vol. 59, # 46 p. 9101 - 9109

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Citation Number: 69

Abstract

A highly efficient two-step chemoenzymatic synthesis of structured triacylglycerols comprising a pure n-3 polyunsaturated fatty acid at the mid-position and a pure saturated fatty acid located at the end-positions is described. In the first step an immobilized Candida antarctica lipase was observed to display an excellent regioselectivity toward the end- positions of glycerol at 0–4° C using vinyl esters as acylating agents. The n-3 fatty acids ...