Iodine-125-labeled 8-phenylxanthine derivatives: antagonist radioligands for adenosine A1 receptors

J Linden, A Patel, CQ Earl, RH Craig…

Index: Linden; Patel; Earl; Craig; Daluge Journal of medicinal chemistry, 1988 , vol. 31, # 4 p. 745 - 751

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Citation Number: 41

Abstract

A series of 8-phenylxanthine derivatives has been synthesized with oxyacetic acid on the para phenyl position to increase aqueous solubility and minimize nonspecific binding and iodinatable groups on the 1-or 3-position of the xanthine ring. The structure-activity relationship for binding of these compounds to A, adenosine receptors of bovine and rat brain and A, receptors of human platelets was examined. The addition of arylamine or ...