Chemistry Letters

NiCl2 (PPh3) 2-Zn Promoted Deallyloxycarbonylative Directed Aldo Reaction of Allyl. BETA.-Keto Carboxylates with Aldehydes to. BETA.-Hydroxy Ketones.

J Nokami, H Konishi, H Matsuura

Index: Nokami, Junzo; Konishi, Haruhisa; Matsuura, Hiroyuki Chemistry Letters, 1991 , p. 2023 - 2026

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Citation Number: 2

Abstract

Regie-and chemospecific deallyloxycarbonylative aldol reaction of allyl (or-lie) α, α- disubstituted β-keto carboxylate with aldehyde was effectively promoted by Ni 0 (NiCl 2 (PPh 3) 2–Zn), in which the allyloxycarbonyl group (–COOCH 2 CH= CH 2) was replaced to 1- hydroxyalkyl group (–CH (OH) R, R= alkyl, vinyl, aryl) under mild reaction conditions.