Synthesis of (3′, 3′??Dimethyloxiranyl) quinones and (Dimethylacetyl) quinones as Potential Cytostatics

…, J Młochowski, L Syper, M Mordarski

Index: Kloc, Krystian; Mlochowski, Jacek; Syper, Ludwik; Mordarski, Marian Journal fuer Praktische Chemie (Leipzig), 1986 , vol. 328, # 3 p. 419 - 429

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Citation Number: 3

Abstract

Abstract 1, 4-Benzoquinones and 1, 4-naphthoquinones carrying 3′, 3′-dimethyloxiranyl, dimethylacetyl or oxiranylmethyloxy substituents (1, 2 or 3) have been synthesized. The methods presented involved epoxidation of a sterically overcrowded double bond as a crucial step for synthesis of (3′, 3′-dimethyloxiranyl) quinones 1. Reaction of aryllithium derivatives with 2-chloro-2-methyl-propanol unexpectedly led to (dimethyl) acetylarenes ...