Studies on the mechanism of action of azinomycin B: definition of regioselectivity and sequence selectivity of DNA cross-link formation and clarification of the role of …

RS Coleman, RJ Perez, CH Burk…

Index: Coleman, Robert S.; Perez, Ronelito J.; Burk, Christopher H.; Navarro, Antonio Journal of the American Chemical Society, 2002 , vol. 124, # 44 p. 13008 - 13017

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Citation Number: 66

Abstract

Evaluation of the sequence selectivity, noncovalent association, and orientation of the DNA cross-linking agent azinomycin B on its duplex DNA receptor is described. A strong correlation between sequence nucleophilicity and cross-linking yield was observed, and steric effects due to the thymine C5-methyl group were identified. Detailed studies on the role of the azinomycin naphthoate using viscometry, fluorescence contact energy transfer, ...