Efficient Construction of the Clerodane Decalin Core by an Asymmetric Morita–Baylis–Hillman Reaction/Lewis Acid Promoted Annulation Strategy

SA Rodgen, SE Schaus

Index: Rodgen, Stacy A.; Schaus, Scott E. Angewandte Chemie - International Edition, 2006 , vol. 45, # 30 p. 4929 - 4932

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Citation Number: 40

Abstract

The clerodane class of natural products are diterpenes that exhibit wide-ranging structural diversity.[1] Over 150 new bioactive clerodanes have been reported since 2002.[2] Of particular interest are asmarinesA (1) and B (2)[3] and popolohuanone E (3),[4] members of this class of natural products that exhibit potent antiproliferative activity against several types of human-cancer-cell lines (Scheme 1).[5] Popolohuanone E is a topoisomerase II ...