Synthesis and antibacterial activity of some 3-hydroxyquinolones

S Rádl, M Janichová

Index: Radl, Stanislav; Janichova, Magda Collection of Czechoslovak Chemical Communications, 1992 , vol. 57, # 1 p. 188 - 193

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Citation Number: 6

Abstract

Abstract A reductive decarboxylation of 7-chloro-1-ethyl-6-fluoro-1, 4-dihydro-4- oxoquinoline-3-carboxylic acid (Id) with sodium borohydride provided the respective 1, 2, 3, 4-tetrahydro derivative Va, which was treated with selenium dioxide to give product of dehydrogenation VIa. 3-Acetyl-1-ethyl-1, 4-dihydroquinolin-4-ones VIb and VIc were oxidized with 3-chloroperoxybenzoic acid to the respective 3-hydroxyderivatives IIIa and ...