2-(Substituted phenyl) amino analogs of 1-methoxyspirobrassinol methyl ether: Synthesis and anticancer activity
…, R Mezencev, J Mojžiš, M Pilátová, E Balentová…
Index: Kutschy, Peter; Salayova, Aneta; Curillova, Zuzana; Kozar, Tibor; Mezencev, Roman; Mojzis, Jan; Pilatova, Martina; Balentova, Eva; Pazdera, Pavel; Sabol, Marian; Zburova, Michaela Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 10 p. 3698 - 3712
Full Text: HTML
Citation Number: 29
Abstract
New analogs of indole phytoalexin 1-methoxyspirobrassinol methyl ether have been designed by replacement of its 2-methoxy group with 2-(substituted phenyl) amino group. Synthesized by spirocyclization methodology, trans-and cis-diastereoisomers of target compounds were isolated and evaluated as potential anticancer and antimicrobial agents. Their molecular geometries were refined by ab initio minimizations. Pharmacophore ...
Related Articles:
Rhe first total syntheses of 9-methoxycarbazole-3-carboxaldehyde and
[Kawasaki, Toshiya; Somei, Masanori Heterocycles, 1990 , vol. 31, # 9 p. 1605 - 1608]
[Budovska, Mariana RSC Advances, 2014 , vol. 4, # 11 p. 5575 - 5582]
A simple synthesis of a phytoalexin, methoxybrassinin
[Somei, Masanori; Kobayashi, Kensuke; Shimizu, Kazuhisa; Kawasaki, Toshiya Heterocycles, 1992 , vol. 33, # 1 p. 77 - 80]
A simple synthesis of a phytoalexin, methoxybrassinin
[Somei, Masanori; Kobayashi, Kensuke; Shimizu, Kazuhisa; Kawasaki, Toshiya Heterocycles, 1992 , vol. 33, # 1 p. 77 - 80]
A simple synthesis of a phytoalexin, methoxybrassinin
[Somei, Masanori; Kobayashi, Kensuke; Shimizu, Kazuhisa; Kawasaki, Toshiya Heterocycles, 1992 , vol. 33, # 1 p. 77 - 80]