Canadian journal of chemistry

Synthesis and in vitro activity of several new carbapenems

Y Ueda, V Vinet

Index: Ueda, Yasutsugu; Vinet, Viviane Canadian Journal of Chemistry, 1986 , vol. 64, p. 2184 - 2191

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Citation Number: 3

Abstract

The synthesis and in vitro activity of several new carbapenems, 2-(3-cis-substituted cyclopentylthio)-and 2-(4-cis-substituted cyclohexylthio)-(6 S)-[(1'R)-hydroxyethyl]-(5 R)- carbapen-2-em-3-carboxylic acids 7 and 8, are described. The synthesis involves the stereospecific preparation of cis-substituted cyclopentyl-and cyclohexylthiols 2 and 3 by the hetero Diels-Alder reaction followed by some chemical manipulations.