Synthesis and antiviral activity of enantiomeric forms of cyclobutyl nucleoside analogs

GS Bisacchi, A Braitman, CW Cianci…

Index: Bisacchi; Braitman; Cianci; Clark; Field; Hagen; Hockstein; Malley; Mitt; Slusarchyk; Sundeen; Terry; Tuomari; Weaver; Young; Zahler Journal of Medicinal Chemistry, 1991 , vol. 34, # 4 p. 1415 - 1421

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Citation Number: 95

Abstract

We felt it important to synthesize and test separately for antiviral activity each enantiomer corresponding to these racemates, ie the enantiomers 7 and 8 that comprise racemate 5 and the enantiomers 9 and 10 that comprise racemate 6.1 The relationship of the hydroxy and base moieties in enantiomers 7 and 9 corresponds to that in the naturally occurring nucleosides 2'-deoxyguanosine (1 1) and 2'-deoxyadenosine (12), respectively. In the ...