Tetrahedron: Asymmetry

Preparation of halohydrin β-blocker precursors using yeast-catalysed reduction

…, C Del Campo, JV Sinisterra, EF Llama

Index: Martinez, Fernando; Del Campo, Carmen; Sinisterra; Llama, Emilio F. Tetrahedron Asymmetry, 2000 , vol. 11, # 23 p. 4651 - 4660

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Citation Number: 23

Abstract

The preparation of halohydrin β-blocker precursors using yeast-catalysed reduction of α- haloketones was performed. The influence in the yield and ee of several process variables was analysed. The (S)-enantioselectivity observed with Saccharomyces cerevisiae can be changed to (R)-enantioselectivity using methyl vinyl ketone as selective inhibitor (25 mM). Using resting fresh cells better yields and ees are observed than using growing cells. ...