New observations on peptide bond formation using CDMT
CE Garrett, X Jiang, K Prasad, O Repič
Index: Garrett, Christine E.; Jiang, Xinglong; Prasad, Kapa; Repic, Oljan Tetrahedron Letters, 2002 , vol. 43, # 23 p. 4161 - 4165
Full Text: HTML
Citation Number: 37
Abstract
The optimized formation of the peptide bond by means of 2-chloro-4, 6-dimethoxy-1, 3, 5- triazine (CDMT) has been found to occur rapidly and essentially quantitatively in a one-pot, one-step procedure. This new method is effective for the coupling of a variety of reactive partners, including chiral amino acids (eg N-acetyl-l-leucine) without significant loss of configuration. Significant racemization was observed when the typical literature conditions ...
Related Articles:
[Hioki, Kazuhito; Kameyama, Satomi; Tani, Shohei; Kunishima, Munetaka Chemical and Pharmaceutical Bulletin, 2007 , vol. 55, # 5 p. 825 - 828]
Ruthenium-catalysed oxidation of alcohols to amides using a hydrogen acceptor
[Watson, Andrew J.A.; Wakeham, Russell J.; Maxwell, Aoife C.; Williams, Jonathan M.J. Tetrahedron, 2014 , vol. 70, # 23 p. 3683 - 3690]
[Barton, Derek H. R.; Jaszberenyi, Joseph Cs.; Theodorakis, Emmanouil A.; Reibenspies Journal of the American Chemical Society, 1993 , vol. 115, # 18 p. 8050 - 8059]
Metal-free oxidative amide formation with N-hydroxysuccinimide and hypervalent iodine reagents
[Yao, Haoyi; Tang, Yun; Yamamoto, Kana Tetrahedron Letters, 2012 , vol. 53, # 38 p. 5094 - 5098]
[Sheikh, Md. Chanmiya; Takagi, Shunsuke; Yoshimura, Toshiaki; Morita, Hiroyuki Tetrahedron, 2010 , vol. 66, # 36 p. 7272 - 7278]