Tetrahedron Letters

Novel synthesis of 2-thiazolines

X Fernandez, R Fellous, E Duñach

Index: Fernandez, Xavier; Fellous, Roland; Dunach, Elisabet Tetrahedron Letters, 2000 , vol. 41, # 18 p. 3381 - 3384

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Citation Number: 45

Abstract

The synthesis of a series of 2-thiazolines was carried out under mild conditions from the corresponding thiazolidines, by a Ru-catalyzed/TBHP oxidation reaction conditions. The reaction was chemoselective towards the amine-imine oxidation and was also regioselective, affording the unsaturation at the 2-position of the heterocycle, even with thiazolidine substrates bearing ester groups at the 4-position.