… –Activity Relationship Studies of Novel 2-Diarylethyl Substituted (2-Carboxycycloprop-1-yl) glycines as High-Affinity Group II Metabotropic Glutamate Receptor …

…, BG Johnson, DD Schoepp, PL Ornstein

Index: Sorensen, Ulrik S; Bleisch, Thomas J; Kingston, Anne E; Wright, Rebecca A; Johnson, Bryan G; Schoepp, Darryle D; Ornstein, Paul L Bioorganic and medicinal chemistry, 2003 , vol. 11, # 2 p. 197 - 205

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Citation Number: 15

Abstract

The major excitatory neurotransmitter in the central nervous system,(S)-glutamic acid (1), activates both ionotropic and metabotropic excitatory amino acid receptors. Its importance in connection to neurological and psychiatric disorders has directed great attention to the development of compounds that modulate the effects of this endogenous ligand. Whereas l- carboxycyclopropylglycine (l-CCG-1, 2) is a potent agonist at, primarily, group II ...