Synthesis of an Enkephalin Analogue Containing an α, α-Disubstituted Heterocyclic Aminophosphonic Acid

N Rabasso, A Fadel

Index: Rabasso, Nicolas; Fadel, Antoine Phosphorus, Sulfur and Silicon and the Related Elements, 2011 , vol. 186, # 8 p. 1811 - 1819

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Abstract

Abstract Synthesis of a phosphonopentapeptide enkephalin analogue was achieved from heterocyclic aminophosphonates via the coupling of Boc-Tyr-Gly-Gly-OH with phosphonodipeptide. The latter was formed by coupling Boc-Phe-OH with N-terminal α, α- disubstituted heterocyclic α-aminophosphonates. GRAPHICAL ABSTRACT