Advanced Synthesis & Catalysis

Sodium Nitrite??Catalyzed Aerobic Oxidative Csp2 Csp3 Coupling: Direct Construction of the 4??Aryldihydroisoquinolinone Moiety

B Su, M Deng, Q Wang

Index: Su, Bo; Deng, Meng; Wang, Qingmin Advanced Synthesis and Catalysis, 2014 , vol. 356, # 5 p. 977 - 981

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Abstract

Abstract: A bioinspired approach for the construction of the 4-aryldihydroisoquinolinone moiety via direct oxidative Csp2ÀCsp3 coupling has been developed, which uses inexpensive sodium nitrite as catalyst and environmentally benign oxygen in the air as terminal oxidant. Keywords: 4-arylisoquinolinones; biogenetic synthesis; cherylline; oxidative coupling reaction; sodium nitrite