Three??Component Synthesis of Indanone??Fused Spirooxindole Derivatives

XB Chen, XM Liu, R Huang, SJ Yan…

Index: Chen, Xue-Bing; Liu, Xi-Ming; Huang, Rong; Yan, Sheng-Jiao; Lin, Jun European Journal of Organic Chemistry, 2013 , # 21 p. 4607 - 4613

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Citation Number: 11

Abstract

Abstract A simple, straightforward and versatile multicomponent protocol for the synthesis of indanone-fused spirooxindole derivatives has been developed. The strategy involves the one-pot three-component reaction of heterocyclic ketene aminals, 1H-indene-1, 3 (2H)- dione and the dicarbonyl compounds isatins or acenaphthenequinone in an ethanol/water medium catalysed by p-TSA at reflux. Mild reaction conditions, operational simplicity, wide ...