Diversity Oriented Approach to Polycyclic Compounds through the Diels–Alder Reaction and the Suzuki Coupling

S Kotha, S Misra, V Srinivas

Index: Kotha, Sambasivarao; Misra, Shilpi; Srinivas, Venu European Journal of Organic Chemistry, 2012 , # 21 p. 4052 - 4062

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Citation Number: 5

Abstract

Abstract A diversity oriented strategy has been demonstrated to deliver small “drug like” molecules using alkylation, Diels–Alder reaction, and Suzuki–Miyaura cross-coupling as key steps. This methodology allows access a wide range of molecules using simple scaffolds such as indanes, tetralins and tetrahydroisoquinolines, which can enhance the chemical space for potential therapeutic molecules.