Pyrazolo [3, 4-d] pyrimidine ribonucleosides as anticoccidials. 3. Synthesis and activity of some nucleosides of 4-[(arylalkenyl) thio] pyrazolo [3, 4-d] pyrimidines

JL Rideout, TA Krenitsky, EY Chao…

Index: Rideout, Janet L.; Krenitsky, Thomas A.; Chao, Esther Y.; Elion, Gertrude B.; Williams, Raymond B.; Latter, Victoria S. Journal of Medicinal Chemistry, 1983 , vol. 26, # 10 p. 1489 - 1494

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Citation Number: 14

Abstract

Ribonucleosides of 4-(alkylthio)-1H-pyrazolo [3, 4-d] pyrimidines have been shown to be useful anticoccidial agents [Krenitsky, TA; Rideout, JL; Koszalka, GW; Inmon, RB; Chao, EY; Elion, GB; Latter, VS; Williams, RB J. Med. Chem. 1982, 25, 32. Rideout, JL; Krenitsky, TA; Elion, GBUS Patent 4299283, 19811, In that study, the unsaturated 4-allylthio and 4- crotylthio derivatives (19 and 20) were shown to be more active in vivo against Eimeria ...