Tetrahedron Letters

The first synthesis of β-amino phosphonates using cyclic sulfamidates

B Das, CR Reddy, S Nagendra, M Lingaiah

Index: Das, Biswanath; Reddy, Cheruku Ravindra; Nagendra, Siddavatam; Lingaiah, Maram Tetrahedron Letters, 2011 , vol. 52, # 27 p. 3496 - 3498

Full Text: HTML

Citation Number: 5

Abstract

Abstract Cyclic sulfamidates (prepared from α-amino acids and β-amino alcohols) have been used for the first time for the synthesis of novel β-amino phosphonates (chiral and achiral) by treatment with dialkyl phosphites using sodium hydride. 2-Substituted and 1, 2- disubtituted β-amino phosphonates have efficiently been prepared following this method. The products are formed in high yield (79–84%) within 8–12 h.