Antispasmodics. II. Derivatives of N-substituted-3-piperidols

JH Biel, EP Sprengeler, HA Leiser…

Index: Biel et al. Journal of the American Chemical Society, 1955 , vol. 77, p. 2250,2252

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Citation Number: 44

Abstract

A similar method has recently been described for the preparation of phenyl-3-thienylglycolic acid. I4 The 3-mercaptopiperidines were obtained by the condensation of the 3-chloro derivatives with thioacetic acid in refluxing isopropyl alcohol followed by a mild alkaline hydrolysis of the thioacetates and a continuous ether extraction of the neutral solution.