Synthesis and activity of 6-aryl-3-(hydroxypolymethyleneamino) pyridazines in animal models of epilepsy

A Hallot, R Brodin, J Merlier, J Brochard…

Index: Hallot; Brodin; Merlier; Brochard; Chambon; Biziere Journal of Medicinal Chemistry, 1986 , vol. 29, # 3 p. 369 - 375

Full Text: HTML

Citation Number: 28

Abstract

In the course of our search for new antiepileptic drugs we synthesized a 6-phenyl-3- aminopyridazine derivative [6-(2-chlorophenyl)-3-(4-hydroxypiperidino) pyridazine], which proved to be an orally active, potent anticonvulsant in a variety of animal models of epilep~ y.'~ To this day, only four series of 6-phenyl-3-aminopyridazines have been described for their activity on the central nervous system. 16 Minaprine has been found active in animal ...