Intramolecular Cyclization of Some Acyclic Nucleoside Analogs

…, A Holý, H Votavová, M Masojídková

Index: Janeba, Zlatko; Holy, Antonin; Votavova, Hana; Masojidkova, Milena Collection of Czechoslovak Chemical Communications, 1996 , vol. 61, # 3 p. 442 - 457

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Citation Number: 12

Abstract

Abstract Reaction of stereoisomeric 8-bromo-9-(2, 3-O-isopropylidene-2, 3, 4- trihydroxybutyl) adenines (8) with concentrated aqueous ammonia, sodium hydride, potassium tert-butoxide, or 1, 8-diazabicyclo [5, 4, 0] undec-7-ene afforded 4e-O, 8-anhydro- 9-(2, 3-O-isopropylidene-2, 3, 4-trihydroxybutyl) adenines 9 (derivatives of 1, 3-oxazepino [2, 3-e] adenine). The CD spectra of optically active stereoisomers of 9 have been studied ...

7'-substituted benzothiazolothio-and pyridinothiazolothio-purines as potent heat shock protein 90 inhibitors

[Zhang, Lin; Fan, Junhua; Vu, Khang; Hong, Kevin; Le Brazidec, Jean-Yves; Shi, Jiandong; Biamonte, Marco; Busch, David J.; Lough, Rachel E.; Grecko, Roy; Ran, Yingqing; Sensintaffar, John L.; Kamal, Adeela; Lundgren, Karen; Burrows, Francis J.; Mansfield, Robert; Timony, Gregg A.; Ulm, Edgar H.; Kasibhatla, Srinivas R.; Boehm, Marcus F. Journal of Medicinal Chemistry, 2006 , vol. 49, # 17 p. 5352 - 5362]

7'-substituted benzothiazolothio-and pyridinothiazolothio-purines as potent heat shock protein 90 inhibitors

Intramolecular Cyclization of Some Acyclic Nucleoside Analogs

Abstract

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