Synlett

α-Formylation of α-Substituted Ketones

J Hassan, CJ Richards

Index: Hassan, Jamal; Richards, Christopher J. Synlett, 2012 , # 2 p. 239 - 242

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Citation Number: 1

Abstract

Abstract The reaction of (chloromethylene) dimethylammonium chloride (generated in situ from oxalyl chloride and DMF) with α-substituted ketones in CH 2 Cl 2, followed by workup with aqueous NaHCO 3, gave β-keto aldehydes containing an α-quaternary centre (8-88% yield).