MWI-promoted preparation of 4H-thiopyran derivatives through one-pot multi-component reactions

X Fan, X Wang, X Zhang, X Li…

Index: Fan, Xuesen; Wang, Xia; Zhang, Xinying; Li, Xiaoyan; Qu, Guirong Journal of Chemical Research, 2007 , # 12 p. 693 - 695

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Citation Number: 5

Abstract

One-pot reaction of aromatic aldehydes, cyanothioacetamide and malononitrile under microwave irradiation proved to be an efficient way for the synthesis of 2,6-diamino-4-aryl-4H-thiopyran-3 ,5-dicarbonitriles without any added catalyst. ... Keywords: microwave heating, thioamides, malononitrile, 4H-thiopyrans, multi-component reactions ... Recently thiopyran derivatives have gained increasing attention due to their importance as key units in medicinal chemistry ...