Stereoselective synthesis of unnatural aminoacids cis-4-hydroxyproline and bulgecinine
A Madau, G Porzi, S Sandri
Index: Madau, Alessandra; Porzi, Gianni; Sandri, Sergio Tetrahedron Asymmetry, 1996 , vol. 7, # 3 p. 825 - 830
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Citation Number: 26
Abstract
A new stereoselective synthesis of both (2R, 4R)-and (2S, 4S)-4-hydroxy-proline and (+)- and (−)-bulgecinine was performed starting from synthons 1 or 1′, respectively. The synthetic route has been established via a novel assisted cleavage of a disubstituted amide in mild conditions and successive stereocontrolled iodocyclization (Schemes 1 and 2).
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