Isolation, structural elucidation, and biosynthesis of 15-norlankamycin derivatives produced by a type-II thioesterase disruptant of Streptomyces rochei
K Arakawa, Z Cao, N Suzuki, H Kinashi
Index: Arakawa, Kenji; Cao, Zhisheng; Suzuki, Natsumi; Kinashi, Haruyasu Tetrahedron, 2011 , vol. 67, # 29 p. 5199 - 5205
Full Text: HTML
Citation Number: 3
Abstract
Abstract Lankamycin, a 14-membered macrolide antibiotic, contains a 3-hydroxy-2-butyl side chain at C-13. To analyze the function of lkmE, which encodes type-II thioesterase in the lankamycin cluster, we carried out a gene disruption experiment. Disruption of lkmE resulted in a 70% decrease of lankamycin production concomitant with an accumulation of novel lankamycin derivatives (LM-NS01A and LM-NS01B), in which the C-13 side chain is ...
Related Articles:
Synthesis of (25R)-cholest-5-ene-3β, 26-diol and its radiolabeled analog
[D'Ambra, Thomas E.; Javitt, Norman B.; Nakanishi, Koji; Warchol, Tadeusz Tetrahedron Letters, 1997 , vol. 38, # 22 p. 3801 - 3804]
[Kozikowski,, Alan P.; Ghosh, Arun K. Journal of Organic Chemistry, 1984 , vol. 49, # 15 p. 2762 - 2772]