Tetrahedron

Nonenzymatic kinetic resolution of racemic 2, 2, 2-trifluoro-1-aryl ethanol via enantioselective acylation

Q Xu, H Zhou, X Geng, P Chen

Index: Xu, Qing; Zhou, Hui; Geng, Xiaohong; Chen, Peiran Tetrahedron, 2009 , vol. 65, # 11 p. 2232 - 2238

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Citation Number: 40

Abstract

Kinetic resolution of a series of 2, 2, 2-trifluoro-1-aryl ethanol with (R)-benzotetramisole as the catalyst has been investigated. The result showed that when the aryl group in the substrate was a phenyl (or a phenyl substituted by an electron-donating group) or a naphthyl (an extended phenyl) group, the system could give an s value higher than 20. Preparative KR examples demonstrated the applicability of this method in the preparation of some of ...