Helvetica chimica acta

Synthesen und Untersuchungen von [Oxazolo [2, 3??a] isoindol??9b (2H)??yl] phosphonaten und??phosphinaten: Eine neue Klasse von Heterocyclen

R Neidlein, P Greulich, W Kramer

Index: Neidlein, Richard; Greulich, Peter; Kramer, Walter Helvetica Chimica Acta, 1993 , vol. 76, # 6 p. 2407 - 2417

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Citation Number: 10

Abstract

We attempted to synthesize diethyl (I-methyl-2-phthaErnidoethy1) phosphonate (14a) in a Miehaelis-Beeker reaction using diethyl sodiophosphonate (13) and the tosylate 12a of (2- hydroxypropy1) phthalimide as starting materials. Instead of TsO substitution in 1Za by the nucleophile 13, the carbonyl C-atom of the phthalimido moiety was attacked by 13, followed by an intramolecular nucleophilic substitution at C (2) of the side chain leading to the ( ...