tris (2-Carboxyethyl) phosphine (TCEP) for the reduction of sulfoxides, sulfonylchlorides, N-oxides, and azides

AM Faucher, C Grand-Maître

Index: Faucher, Anne-Marie; Grand-Maitre, Chantal Synthetic Communications, 2003 , vol. 33, # 20 p. 3503 - 3511

Full Text: HTML

Citation Number: 16

Abstract

INTRODUCTION tris (2-Carboxyethyl) phosphine (TCEP), commercially available as a hydrochloride complex, is an efficient reducing agent most commonly used to reduce disulfide bonds. It is a good substitute for dithiothreitol (DTT) to prevent the formation of intramolecular disulfide bridges in protein, thus preserving their bioactive secondary structure.[1–3] Other uses of TCEP seem to be limited to an analytical tool used for the ...