The First Enantioselective Approach to 13a??Methyl??14??hydroxyphenanthroindolizidine Alkaloids–Synthetic Studies towards Hypoestestatin 2

B Su, M Deng, Q Wang

Index: Su, Bo; Deng, Meng; Wang, Qingmin European Journal of Organic Chemistry, 2013 , # 10 p. 1979 - 1985

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Citation Number: 2

Abstract

Abstract The first enantioselective approach to 13a-methyl-14- hydroxyphenanthroindolizidine alkaloids was achieved in six linear steps from phenanthryl alcohol and features a highly substrate-dependent Parham cycloacylation and Seebach's enantioselective alkylation as the key steps. The route is concise, protecting-group free, provides access to all stereoisomers, and works on a gram scale. In addition to the ...