Bioorganic & medicinal chemistry

… synthesis of the serotonin 5-HT 2A receptor antagonist MDL 100907, its enantiomer and their 3-phenolic derivatives as precursors for [11 C] labeled PET ligands

T Ullrich, KC Rice

Index: Ullrich, Thomas; Rice, Kenner C. Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 10 p. 2427 - 2432

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Citation Number: 33

Abstract

A practical synthesis of the 3-phenolic precursor of MDL 100907, a selective 5-HT2A receptor antagonist, is described. The route was also applied to the enantiomeric series, thus affording the direct precursors of both 3-[11C] MDL 100907 and its enantiomer as ligands for positron emission tomography. Similar methodology was developed for the direct synthesis of MDL 100907 and its enantiomer, MDL 100009. The routes utilized classical ...