Tetrahedron Letters

Controlled derivatization of polyhalogenated quinolines utilizing selective cross-coupling reactions

MB Nolt, Z Zhao, SE Wolkenberg

Index: Brad Nolt; Zhao, Zhijian; Wolkenberg, Scott E. Tetrahedron Letters, 2008 , vol. 49, # 19 p. 3137 - 3141

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Citation Number: 22

Abstract

Straightforward procedures for the derivatization of tri-and tetrahalogenated quinolines utilizing sequential selective Pd-catalyzed cross-coupling reactions are described. Taking advantage of intrinsic halide reactivity, substrate control, and appropriate reaction conditions, highly selective reactions at the quinoline 3-, 4-, and 6-position are possible.