5-HT2C receptor agonists for the treatment of obesity. Biological and chemical adventures

D Adams, A Bénardeau, MJ Bickerdike…

Index: Adams, David; Benardeau, Agnes; Bickerdike, Mike J.; Bentley, Jon M.; Bissantz, Caterina; Bourson, Anne; Cliffe, Ian A.; Hebeisen, Paul; Kennett, Guy A.; Knight, Antony R.; Malcolm, Craig S.; Mizrahi, Jacques; Plancher, Jean-Marc; Richter, Hans; Roever, Stephan; Taylor, Sven; Vickers, Steven P. Chimia, 2004 , vol. 58, # 9 p. 613 - 620

Full Text: HTML

Citation Number: 11

Abstract

Obesity is a major risk factor in the development of conditions such as hypertension, hyperglycemia, dyslipidemia, coronary artery disease and cancer. There is increasing evidence suggesting an important role for the 5-HT2C receptor in appetite control. Collaboration between F. Hoffmann-La Roche Ltd and Vernalis Research Ltd has allowed rapid construction of a solid structure–activity relationship around a pyrroloindole core. A ...