Synthesis of pyrimidin-2-one nucleosides as acid-stable inhibitors of cytidine deaminase

CH Kim, VE Marquez, DT Mao, DR Haines…

Index: Kim, Chong-Ho; Marquez, Victor E.; Mao, David T.; Haines, David R.; McCormack, John J. Journal of Medicinal Chemistry, 1986 , vol. 29, # 8 p. 1374 - 1380

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Citation Number: 71

Abstract

HO OH Figure 1. Structure-activity relationships of transition-state inhibitors for adenosine deaminase (ADA) and cytidine deaminase (CDA). the seven-membered ring diazepinone nucleosides with the acid stability and antitumor properties of the aromatic six-membered 2- oxopyrimidine nucleoside 1. At the same time, it was also of interest to study the extent to which the six-membered aglycon ring in 1 allowed itself to be altered in order to resemble ...