Synthesis and evaluation of opioid receptor-binding affinity of elaeocarpenine and its analogs

H Kurasaki, I Okamoto, N Morita, O Tamura

Index: Kurasaki, Haruaki; Okamoto, Iwao; Morita, Nobuyoshi; Tamura, Osamu Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 5 p. 1601 - 1603

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Citation Number: 8

Abstract

Both enantiomers of elaeocarpenine (1) and its analogs, 21, 22, 25, and 27, were synthesized from bicyclic aldehydes 8–10 via a flexible route previously established for total synthesis of grandisines, and their binding affinities for μ-, κ-and δ-opioid receptor ...