Rapid access to amino-substituted quinoline,(di) benzofuran, and carbazole heterocycles through an aminobenzannulation reaction
M Tiano, P Belmont
Index: Tiano, Martin; Belmont, Philippe Journal of Organic Chemistry, 2008 , vol. 73, # 11 p. 4101 - 4109
Full Text: HTML
Citation Number: 47
Abstract
The use of a powerful aminobenzannulation reaction has been applied for the synthesis of amino-substituted quinolines, dibenzofurans, and carbazoles. The precursors are heterocycles bearing a methyl ketone group ortho to an internal alkyne. They are commercially available or can be obtained in three to four classical and efficient reactions: Vilsmeier− Haack, Sonogashira (diversity point), Grignard, and Ley's oxidation. Upon ...
Related Articles:
[Romero; Morge; Biles; Berrios-Pena; May; Palmer; Johnson; Smith; Busso; Tan; Voorman; Reusser; Althaus; Downey; So; Resnick; Tarpley; Aristoff Journal of Medicinal Chemistry, 1994 , vol. 37, # 7 p. 999 - 1014]
[Mallet, Marc; Branger, Gilles; Marsais, Francis; Queguiner, Guy Journal of Organometallic Chemistry, 1990 , vol. 382, # 3 p. 319 - 332]